A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy’s and Wilson’s suspicions that something is terribly wrong.

Wilson (Robert Sean Leonard, C) and Cuddy (Lisa Edelstein, R) are surprised to learn that House (Hugh Laurie, L) has found a new way to treat his leg pain in the HOUSE episode “The Softer Side” airing Monday, Feb. 16 (8:00-9:00 PM ET/PT) on FOX.
[Photo: ©2009 Fox Broadcasting Co. Cr: Adam Taylor/FOX]

House (Hugh Laurie, L) treats a boy (Dominic Scott Kay, second from L) whose parents (Ben Reed, second from R and Julia Campbell, R) have not been honest with him.
[Photo: ©2009 Fox Broadcasting Co. Cr: Adam Taylor/FOX]

Wilson (Robert Sean Leonard, R) and Cuddy (Lisa Edelstein, C) help House (Hugh Laurie, L) when he experiments with a new treatment for his leg pain.
[Photo: ©2009 Fox Broadcasting Co. Cr: Adam Taylor/FOX]

The team (L-R: Olivia Wilde, Peter Jacobson and Kal Penn) is surprised to see House dealing with his leg pain.
[Photo: ©2009 Fox Broadcasting Co. Cr: Adam Taylor/FOX]

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House hides something from his colleagues and is forced to tell the truth after he is found not breathing. In the next episode of “House M.D.“, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nice. When they discover the shocking answer, they must face the prospect that House may be changed forever.

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy’s parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever in “The Softer Side” episode of HOUSE airing Monday, Feb. 16

“The Softer Side” airs February 23.

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase; Peter Jacobson as Dr. Chris Taub; Kal Penn as Dr. Lawrence Kutner; Olivia Wilde as Thirteen

Guest Cast: Dominic Scott Kay as Jackson; Julia Campbell as Melanie; Ben Reed as Joseph; Nick Puga as Ian; Fred Kronenberg as Doctor; Meagan Gordon as Young Woman; Nicole Cannon as Nurse Helen; Bobbin Bergstrom as Nurse

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House struggles with his own beliefs as he takes on a case of priest with a disturbing past who runs a shelter for homeless people and sees a vision of Jesus.

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Stars: Hugh Laurie (Dr. Gregory House), Omar Epps (Dr. Eric Foreman)
Recurring Role: Olivia Wilde (Thirteen), Bobbin Bergstrom (Nurse)
Guest Star: Jimmi Simpson (Daniel Bresson), Jake Thomas (Ryan), Janet Haley (Eileen), Terrance Ellis (Daryl), Nick Josephs (Man)

Watch House s05e15 “Unfaithful” Preview Video

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Done with the 100th episode, “House M.D.” is moving on with the episode “Unfaithful” where a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep. He is then the case of House and the team after he arrives in the ER.

House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient’s condition takes a drastic turn for the worse, and House grapples with his past and his belief in the “Unfaithful”

The episode airs February 9. Jimmi Simpson (”Late Show with David Letterman”) guest stars as the priest.

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